p53 Cell-Based Activation/Translocation Assay Kit - 96 Well

The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman`s p53 Cell-Based Activation/Translocation Assay Kit provides a highly specific p53 primary monoclonal antibody together with a DyLightTM (product of Pierce Biotechnology, Inc.) conjugated secondary antibody in a ready-to-use format. (-)-Nutlin-3, a potent inhibitor of Mdm2-p53 interaction, which has been shown by scientists at Cayman to cause the activation and translocation of p53 between the cytoplasm and nuclear compartments, is included as a positive control.Application/Cell-Based Assay, Chemical Class/Assay Kits, Research Area/Cancer, Research Area/Signal TransductionSynonyms :