Mouse anti-Cytokeratin 7, clone RN7 - 1 mL

Description :Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. Cytokeratin 7 belongs to the neutral basic type B subfamily of cytokerat ins. Its distribution is confined to glandular and transitional epithelia. Cytokeratin 7 is reported to be expressed in abundance in cultured bronchial and mesothelial cells but only at lower levels in cultured epidermal cells. The predicted amino ac id sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells. Cytokeratin 7 has been reported in adenocarcinomas of the lung, breast, endometrium, ovary, thyroid as well as in carcinomas of the bladder and chromophobe renal cell carcinoma. Cytokeratin 7 and Cytokeratin 20 expression have been reported to show characteristic patterns on primary and metastatic lung and colorectal adenocarcinomas. Applications :IHC-P Species_reactivity :human Clone :RN7 Clonality :Monoclonal Storage_Buffer :Tissue culture supernatant with Sodium azide Concentration :Greater than or equal to 17 mg/L References(General) :(1) van de Molengraft FJJM et al.Histopathology. 1993; 22:35-38 (2) van Niekerk CC et al. Journal of Pathology. 1991; 165(2):145-15