VerifyNow IIb/IIIa Assay - 25 Tests

The VerifyNow⢠IIb/IIIa Assay is an automated, turbidimetric, whole- blood assay designed to assess platelet function based upon the ability of activated platelets to bind to fibrinogen coated beads. The detection well of the VerifyNow⢠IIb/IIIa assay device contains all of the necessary reagents to perform this analysis. Within the well is an activator that induces the platelet to change the conformation of the GP IIb/IIIa receptor to a form that binds fibrinogen. Additionally, the detection well also contains fibrinogen-coated microbeads that bind to activated GP IIb/IIIa receptors. The GP IIb/IIIa receptors on activated platelets will bind to the fibrinogen-coated microbeads and cross link to other microbeads resulting in a clearing of the beads and platelets within the detection well. The instrument uses light transmittance to measure the rate at which this clearing occurs. If the GP IIb/IIIa receptors on the platelet are inhibited by abciximab or eptifibatide, there will be minimal binding of the microbeads with activated platelets, since the GP IIb/IIIa receptor sites are blocked by the drug and cannot bind to the fibrinogen coated beads. In this instance, there will be minimal clearing of the sample, and very little change in the amount of light that is transmitted through the sample. Application:Used to assess platelet function based upon the ability of activated platelets to bind to fibrinogen coated beads. Method:Immunoassay Species:Human Sample Type:Whole blood SStorage:8 weeks at Room Temp (18 to 25°C), or until expiration date at 2 to 8°C.